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Product :

Paxalisib (GDC-0084)

Paxalisib (GDC-0084) 1382979-44-3
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Chemical Information
Product name：Paxalisib (GDC-0084) Purity：98% min
CAS NO：1382979-44-3 Solubility：in DMSO
Molecular Formula：C18H22N8O2 Package：Package according to customer requirements
Molecular Weight：382.42 Storage：-20 ℃
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Remarks
Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively[1].
References
[1]. Heffron TP, et al. Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR. ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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