Research-grade pharmaceutical intermediate. For laboratory research use only; not for direct human or veterinary clinical use.
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1，Synthetic precursor (primary use)
Fumagillol is the core intermediate of fumagillin and TNP-470 (a classic angiogenesis inhibitor) and is a key starting material for the synthesis of these two drug candidates.
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Fumagillin: antiprotozoal (against microsporidia and Giardia lamblia); used in veterinary medicine for nosemosis in honeybees; also used in anti-angiogenesis research.
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TNP-470: an anti-angiogenic lead compound for cancer; used in basic oncology research.
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2，Pharmacological target research tool
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METAP2 (methionine aminopeptidase 2) inhibitor; inhibits endothelial cell proliferation; used in research on angiogenic mechanisms, tumors, and ocular neovascularization.
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In vitro antiparasitic activity: inhibitory activity against Giardia lamblia; used in screening experiments for new antiprotozoal drugs.
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Immunology-related research: can inhibit lymphocyte proliferation; a basic experimental reagent for immunology.
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3，Other research applications
Vascular biology, microbial pathology, and structural modification of lead compounds; used in early-stage in vitro/animal studies in drug discovery and development.