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   CAS NO.    Products Name
   935666-88-9 AZD 1480  more...
   AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Inhibition of Jak2 activity is associated with abrogation of Stat3 nuclear translocation and tumorigenesis. AZD1...
   905586-69-8 AZ 960  more...
   AZ 960 is a novel small molecule JAK2 kinase inhibitor with an IC50 and Ki of 3 mM and 0.45 nM in vitro, respectively. AZ960 was also shown to be active against other kinases, including...
   1056634-68-4 Cyt387  more...
   Cyt387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. Cyt387 has significantly less activity against other kinases,...
   477600-75-2 CP 690550  more...
   The somatic activating janus kinase 2 mutation (JAK2)V617F is detectable in most patients with polycythemia vera (PV). Enzymatic assays indicate that both JAK1 and JAK2 are 100- and 20-...
   941678-49-5 INCB 018424 Ruxolitinib  more...
   INCB018424 is an orally bioavailable JAK inhibitor with potential antineoplastic and immunomodulating activities. INCB018424, a characterized JAK1/JAK2 inhibitor (IC50 values for JAK1, ...
   1229236-86-5 LY2784544  more...
   LY2784544 also inhibits IL-3-activated wild type JAK2 with IC50 of 2.26 μM. Similarly in the proliferation assay, LY2784544 shows antiproliferation activity in JAK2 V617F-driven cells w...
   540737-29-9 Tofacitinib citrate (CP-690550 citrate)  more...
   Tofacitinib inhibits IL-2-mediated human T cell blast proliferation and IL-15-induced CD69 expression with IC50 of 11 nM and 48 nM, respectively. Tofacitinib prevents mixed lymphocyte r...
   936091-14-4 TG101209  more...
   TG101209 is a potent and small molecule JAK2-selective kinase inhibitor with IC50 of 6, 25, 17 and 169 nM for JAK2, FLT3, RET and JAK3, respectively.TG101209 potently prevents myeloprol...
   936091-26-8 1374744-69-0(2ClH.H2O) TG 101348  more...
   TG-101348 is a potent, highly selective and ATP- competitive JAK2 inhibitor with an IC50 of 3 nM for JAK2 and JAK2 V617F. Besides, TG-101348 inhibits Flt3 and Ret with IC50 values of 15...

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