Home Products MSDC-0160;CAY10415
MSDC-0160;CAY10415
Synonyms:
CAS NO: MSDC-0160
Molecular Formula: C19H18N2O4S
Molecular Weight: 370.42
Purity: 98% min
Solubility: In DMSO
Storage: -20 oC
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Remarks: MSDC-0160 is a prototype mTOT-modulating insulin sensitizer [1]. MSDC-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator¨Cactivated receptor-¦Ã (PPAR-¦Ã)-dependent side effects. Co-incubation of islets with MSDC-0160 and IGF-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. MSDC-0160 at 50¦ÌM alone also prevents the loss of insulin content significantly. Besides that, treatment of MSDC-0160 increases the phosphorylation of AMPK and reduces mTOR phosphorylation. Moreover, MSDC-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. In addition, MSDC-0160 exerts prevention of nuclear translocation with ¦Â-catenin localized on the cell membrane or cytoplasm in human ¦Â-cells

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