Home Products ARRY380
CAS NO: 937265-83-3
Molecular Formula: C29H27N7O4S
Molecular Weight: 569.63
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: ARRY-380 is equipotent against truncated p95-HER2 with an IC50 of 7 nM. [1] However, ARRY-380 suppresses EGFR with an IC50 of 4 M. ARRY-380 is about 500-fold selective for HER2 versus EGFR.ARRY-380 significantly prevents the growth of tumor in multiple HER2-dependent tumor xenograft models and displays additive activity in combination with standard-of-care agents.

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