Home Products CHIR-265 or RAF265
CHIR-265 or RAF265
Synonyms: CHIR-265 or RAF265
CAS NO: 927880-90-8
Molecular Formula: C24H16F6N6O
Molecular Weight: 518.41
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: RAF265 (CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 M. RAF is a key component of the RAS/RAF/MEK/ERK signal-transduction pathway, which controls cell proliferation, differentiation, and apoptosis in mammalian cells. Raf265 also has anti-angiogenic activity through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2).

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