Home Products GDC-0879
CAS NO: 905281-76-7
Molecular Formula: C19H18N4O2
Molecular Weight: 334.37
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line .For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879).

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