Home Products AS-252424
AS-252424
Synonyms:
CAS NO: 900515-16-4
Molecular Formula: C14H8FNO4S
Molecular Weight: 305.28
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: AS-252424 is a potent and selective PI3k inhibitor with IC50 of 33 and 935 nM for PI3K and PI3K, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. AS-252424 inhibits human recombinant PI3K, and with IC50 values of 20,000, and 20,000 nM, respectively. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 µM. AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg in a mouse model of peritonitis

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