Home Products AZ-628
AZ-628
Synonyms:
CAS NO: 878739-06-1
Molecular Formula: C27H25N5O2
Molecular Weight: 451.52
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: AZ628 is a potent tyrosine protein inhibitor for wild-type CRAF and BRAF V600E with IC50 of 29 and 34 nM, respectively. AZ628 inhibits activities of preactivated wild-type B-Raf with an IC50 of 105, respectively. AZ628 also suppreses activities of a number of tyrosine protein kinases such as VEGFR2, DDR2, Lyn and Flt1, as well as FMS. [1] AZ628 also prevents anchorage-dependent and -independent growth, gives rise to cell cycle arrest, and triggers apoptosis in colon and melanoma cell lines harboring B-RafV600E mutation. AZ628 is antiangiogenic based on inhibition of VEGFR2.

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