Home Products CAL-101
CAL-101
Synonyms:
CAS NO: 870281-82-6
Molecular Formula: C22H18FN7O
Molecular Weight: 415.42
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: CAL-101 is a potent PI3K p110 inhibitor with an IC50 of 65 nM. CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis. CAL-101 has 40 to 300-fold selectivity compared to other PI3K isoforms. In vitro studies of 0.1 to 10 µM CAL-101 showed inhibition of pAKT expression and/or apoptotic effects against primary chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) cells and against a range of leukemia and lymphoma cell lines.

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