Home Products AF 353
AF 353
Synonyms: RO 4
CAS NO: 865305-30-2
Molecular Formula: C14H17IN4O2
Molecular Weight: 400.21
Purity: 98% min
Solubility: DMSO
Storage: -20°C
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Remarks: AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). IC50 value: pIC50 = 8.0 (pIC50, for P2X3) Target: P2X3/P2X2/3 receptor in vitro: AF-353 is a highly potent inhibitor of ¦Á,¦Â-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. AF-353 also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3).

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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Laninamivir
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XL-765, SAR245409
XMD 8-92
XMD17-109
XL388
Y 27632 dihydrochloride
YS-49
YK 4-279
YM 155
Y320;Y-320
YM90Khydrochloride
Y27632
Zonisamide sodium salt
ZM 241385
Z-VAD-FMK
ZSTK 474
Zotarolimus A179578 ABT 578
Z-JIB-04 (NSC 693627)
ZM323881
ZLN005
Zibotentan
[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
[1,1’-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3S)-3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-5- phenyl-1-pentenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester
 

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