Home Products LY2228820
CAS NO: 862507-23-1
Molecular Formula: C24H29FN6.2CH4O3S
Molecular Weight: 612.74
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: LY2228820 is a novel and potent p38MAPK inhibitor: in vitro kinase enzyme activity showed that the IC50 for p38MAPK and p38MAPK were 7 nM and 3 nM, respectively, while that for p38MAPK, p38MAPK and a panel of 172 additional kinases was more than 20 µM. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs.

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