Home Products Motesanib diphosphate
Motesanib diphosphate
Synonyms: AMG-706
CAS NO: 857876-30-3
Molecular Formula: 569.45
Molecular Weight: 569.45
Purity: 98% min
Solubility: In DMSO
Storage: -20
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Remarks: Motesanib (AMG-706) is an orally bioavailable diphosphate salt of a multiple receptor tyrosine kinase inhibitor with potential antineoplastic activity[1]. This reagent selectively targets and inhibits VEGFR1/2/3(IC50: 2 nM /3 nM /6 nM), PDGFR (84nM), kit (8nM), and Ret (59nM)receptors, thereby inhibiting angiogenesis and cellular proliferation. Oral administration of AMG 706 potently inhibited VEGF-induced angiogenesis in the rat corneal model and induced regression of established A431 xenografts

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