Home Products Amuvatinib MP-470
Amuvatinib MP-470
Synonyms: Amuvatinib MP-470
CAS NO: 850879-09-3
Molecular Formula: C23H21N5O3S
Molecular Weight: 447.51
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: MP-470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 M. MP-470 reduced c-Met phosphorylation and enhanced radiation-induced cell kill by 0.4 logs in SF767 cells. Cells pretreated with MP-470 had more ds DNA damage than cells treated with radiation alone. Mechanistically, MP-470 was shown to inhibit dsDNA break repair and increase apoptosis.

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