Home Products PD 0332991 HCl
PD 0332991 HCl
Synonyms:
CAS NO: 827022-32-2
Molecular Formula: C24H29N7O2.HCl
Molecular Weight: 484.00
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 M. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells.

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