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PCI 24781
Synonyms:
CAS NO: 783355-60-2
Molecular Formula: C21H23N3O5
Molecular Weight: 397.42
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: PCI-24781 (CRA-024781) is a novel broad spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) that shows antitumor activity in vitro and in vivo preclinically and is under evaluation in phase I clinical trials for cancer.PCI-24781 inhibited pure recombinant HDAC1 with a Ki of 0.007 Mmol/L, and also inhibited the other HDAC isozymes HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range.

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