Home Products AZD2281 Olaparib
AZD2281 Olaparib
Synonyms: AZD2281,KU-0059436
CAS NO: 763113-22-0 937799-91-2
Molecular Formula: C24H23FN4O3
Molecular Weight: 434.46
Purity: 99%
Solubility: In DMSO
Storage: −20°C
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Remarks: Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error in a strand of the DNA.IC50 (M):PARP-1= 0.005,PARP-2= 0.001 , PF50=25.8.AZD2281(Olaparib) at 400 mg twice daily is well tolerated and highly active. The toxicity that was seen in BRCA1/BRCA2 carriers was similar to the previously reported toxicity in noncarriers

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