Home Products Regorafenib
Regorafenib
Synonyms: BAY 73-4506
CAS NO: 755037-03-7
Molecular Formula: C21H15ClF4N4O3
Molecular Weight: 482.82
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Regorafenib (BAY 73-4506) binds to and inhibits VEGFR-2 and -3, and tumor cell signaling kinases (RET, KIT, PDGFR, and Raf), which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. Regorafenib (BAY 73-4506) shows potent, oral activity in a wide variety of preclinical xenograft models.

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