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VX702
Synonyms:
CAS NO: 745833-23-2 479543-46-9
Molecular Formula: C19H12F4N4O2
Molecular Weight: 404.32
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF, IL-1, cyclooxygenase (COX)-2, IL-6, IL-12 and IFN , all of which have been demonstrated to play important roles in autoimmune diseases such as rheumatoid arthritis (RA) and/or cardiovascular diseases. In an ex vivo blood assay primed with LPS, VX-702 dose-dependently inhibited the production of IL-6, IL-1 and TNF (IC50 = 59, 122 and 99 ng/ml, respectively)

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