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Neratinib
Synonyms: HKI-272
CAS NO: 698387-09-6
Molecular Formula: C30H29ClN6O3
Molecular Weight: 557.04
Purity: 99%
Solubility: In DMSO
Storage: -20°C
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Remarks: Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.[1] Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

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