Home Products Elvitegravir (GS-9137)
Elvitegravir (GS-9137)
Synonyms:
CAS NO: 697761-98-1
Molecular Formula: C23H23ClFNO5
Molecular Weight: 447.88
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: Elvitegravir inhibits PBMC and PA with IC50 of 0.89 and 20 nM, respectively. Elvitegravir prevents the integration of HIV-1 cDNA through the inhibition of DNA strand transfer. Elvitegravir suppresses the replication of HIV-1, including various subtypes and multiple-drug-resistant clinical isolates, and HIV-2 strains with a 50% effective concentration in the subnanomolar to nanomolar range. Elvitegravir inhibits the replication of HIV-1 clinical isolates carrying NRTI, NNRTI, and PI resistance-associated genotypes. Elvitegravir inhibits the HIV replication at a step that occurs after reverse transcription but before proteolytic cleavage, consistent with the integration step. Elvitegravir inhibits the synthesis of strand transfer products with an IC50 of 54 nM. Elvitegravir blocks integration via the inhibition of IN-mediated strand transfer. Elvitegravir inhibits the integration of the HIV-based vector used as a positive control for the luciferase assay with an EC50 of 0.8 nM, as observed in the MAGI assay with HIV-1IIIB. Elvitegravir suppresses the replication of MLV infection with IC50 of 5.8 nM as well as that of the primate retrovirus SIV (IC50 = 0.5 nM), revealing that IN inhibitors have antiviral activity against a broad range of retroviruses. EVG is active against HIV-1 and HIV-2 and has a serum-free antiviral IC50 of 0.3-0.9 nM in peripheral blood mononuclear cells.

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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WAY-100635 maleate salt
XL019
XEN445
XL-765, SAR245409
XMD 8-92
XMD17-109
XL388
YK 4-279
YS-49
YM90Khydrochloride
Y27632
Y320;Y-320
Y 27632 dihydrochloride
YM 155
Z-VAD-FMK
Zibotentan
ZM323881
Z-JIB-04 (NSC 693627)
Zonisamide sodium salt
Zotarolimus A179578 ABT 578
ZSTK 474
ZM 241385
ZLN005
[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
 

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