Home Products Brivanib alaninate (BMS-582664)
Brivanib alaninate (BMS-582664)
CAS NO: 649735-63-7
Molecular Formula: C22H24FN5O4
Molecular Weight: 441.46
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: BMS-582664 inhibits VEGF-stimulated and FGF-stimulated proliferating of HUVECs with IC50 of 40 nM and 276 nM. BMS-582664 (2 M) significantly inhibits VEGFR2, FGFR1, ERK1/2 and Akt phosphorylation in VEGF- and bFGF-stimulated SK-HEP1 cells and HepG-2 cells, while BMS-582664 alone has little effect on levels of phosphorylated ERK1/2, Akt, VEGFR2, and FGFR1 in nonstimulated cells. BMS-582664 inhibits CYP2C19, CYP3A4(BFC) and CYP3A4 (BzRes) with IC50 of 2.4 M, 0.51 M and 1.6 M, respectively. BMS-582664 exhibits high solid state stability (only 0.3% degradation at 50 with desiccant over a period of 12 weeks) and acceptable solution state stability up to pH 6.5.

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