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AS-604850
Synonyms:
CAS NO: 648449-76-7
Molecular Formula: C11H5F2NO4S
Molecular Weight: 285.2
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: AS-604850 is a selective, ATP-competitive PI3K inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant , , , and isoforms, respectively. AS-604850 shows no notable activity against a wide array of protein kinases at 1 M. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

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