Home Products VX-680 (MK-0457, Tozasertib)
VX-680 (MK-0457, Tozasertib)
Synonyms: VX-680 (MK-0457, Tozasertib)
CAS NO: 639089-54-6
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
Purity: 99%
Solubility: In DMSO
Storage: −20°C 2 years
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Remarks: VX-680 gives rise to a marked decrease in tumor size in a human AML (HL-60) xenograft model. In mude mice treateed with VX-680 at 75 mg/kg, twice a day intraperitoneally (b.i.d. i.p.) for 13 days, mean tumor volumes are reduced by 98%. Tumor growth decrease is dose dependent and significant at a dose of 12.5 mg/kg b.i.d. VX-680 is well tolerated, with a small decrease in body weight observed only at the highest dose. VX-680 also triggers tumor regresson in pancreatic and colon xenograft models. VX-680 also displays potent antitumor activity when infused i.v. in mude rats bearing established HCT116 tumors. A higher dose of VX-680 (2 mg/kg/h) improves efficacy with a 56% decrease in mean tumor volume.

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