Home Products PH 797804
PH 797804
Synonyms:
CAS NO: 586379-66-0
Molecular Formula: C22H19BrF2N2O3
Molecular Weight: 477.30
Purity: 98%
Solubility: In DMSO
Storage: -20°C
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Remarks: PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP kinase with a Ki of 5.8 nM.Additionally, in a human peripheral blood monocyte assay, PH-797804 inhibits hPBMC TNF, exhibiting IC50 of 3.4 nM. Indeed, PH-797804 revealed exceptionally high specificity against MAP kinases and the related kinases. In cellular assays, PH-797804 demonstrated superior potency and selectivity in good line with the biochemical measurements.

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