Home Products BMS-265246
CAS NO: 582315-72-8
Molecular Formula: C18H17F2N3O2
Molecular Weight: 345.34
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 M and prevents A2780 Cytox with IC50 of 0.76 M. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively. BMS265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 M-0.492 M in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity.

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