Home Products A 674563
A 674563
Synonyms:
CAS NO: 552325-73-2
Molecular Formula: C22H22N4O
Molecular Weight: 358.44
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 M. A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells.

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