Home Products PNU120596
PNU120596
Synonyms: PNU-120596
CAS NO: 501925-31-1
Molecular Formula: C13H14ClN3O4
Molecular Weight: 311.72
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: PNU120596 is a potent and selective positive allosteric 7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 M. PNU120596 (PNU 120596, PNU-120596) has no detectable effect on 42, 34 and 910 receptors. Discovered in a high-throughput screen, PNU120596 (PNU 120596, PNU-120596) enhanced agonist-evoked calcium flux mediated by an engineered variant of the human 7 nAChR. Electrophysiology studies demonstrated that PNU120596 (PNU 120596, PNU-120596) increased peak agonist-evoked currents mediated by wild-type receptors and also proved a pronounced prolongation of the triggered response in the continued presence of agonist.

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane
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XEN445
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YS-49
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YM 155
Y 27632 dihydrochloride
YK 4-279
YM90Khydrochloride
Zonisamide sodium salt
ZSTK 474
Zotarolimus A179578 ABT 578
ZM323881
Z-JIB-04 (NSC 693627)
Z-VAD-FMK
ZLN005
Zibotentan
ZM 241385
[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
[1,1’-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3S)-3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-5- phenyl-1-pentenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester
 

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