Home Products Rucaparib (AG-014699,PF-01367338)
Rucaparib (AG-014699,PF-01367338)
CAS NO: 459868-92-9
Molecular Formula: C19H18FN3O.H3PO4
Molecular Weight: 421.36
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
Availability and Price
If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Order       Order Infomation
Shipping and handling fee USD40
Free delivery is qualified when the total value of your order exceeds 500USD
Remarks: Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. The radio-sensitization by Rucaparib is due to downstream inhibition of activation of NF-百B, and is independent of SSB repair inhibition. Rucaparib could target NF-百B activated by DNA damage and overcome toxicity observed with classical NF-百B inhibitors without compromising other vital inflammatory functions. Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 米M in permeabilised D283Med cells.

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Related Products
PARP Inhibitors

None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the Buyer.
Homepage | About Us | Products | News&Events | Custom Synthesis | Order Infomation | Contact Us
Friendly link: molbase   Copyright © Taizhou Crene Biotechnology Co.,Ltd.舀舀嚗頞輻