Home Products Rucaparib (AG-014699,PF-01367338)
Rucaparib (AG-014699,PF-01367338)
Synonyms:
CAS NO: 459868-92-9
Molecular Formula: C19H18FN3O.H3PO4
Molecular Weight: 421.36
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. The radio-sensitization by Rucaparib is due to downstream inhibition of activation of NF-百B, and is independent of SSB repair inhibition. Rucaparib could target NF-百B activated by DNA damage and overcome toxicity observed with classical NF-百B inhibitors without compromising other vital inflammatory functions. Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 米M in permeabilised D283Med cells.

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