Home Products JNJ7706621
JNJ7706621
Synonyms:
CAS NO: 443797-96-4
Molecular Formula: C15H12F2N6O3S
Molecular Weight: 394.36
Purity: 99%
Solubility: In DMSO
Storage: −20°C
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Remarks: JNJ-7706621 also shows some inhibition to VEGF-R2, FGF-R2, and GSK3汕, with IC50 of 154每254 nM. JNJ-7706621 shows inhibitory effect on a panel of human cancer cell types, including HeLa, HCT-116, SK-OV-3, PC3, DU145, A375, MDA-MB-231, MES-SA, and MES-SA/Dx5, with IC50 of 112每514 nM, independent of p53, retinoblastoma, or P-glycoprotein status. JNJ-7706621 is several-fold less potent at inhibiting growth of normal cell types, including MRC-5, HASMC, HUVEC, and HMVEC, with IC50 of 3.67每5.42 米M. In HeLa or U937 cells, JNJ-7706621 (0.5每3 米M) delays exit from G1, arrests cells in G2-M, induces endoreduplication, activates apoptosis, and reduces colony formation. In a HeLa cell line, incremental treatment with increasing concentrations of JNJ-7706621 leads to a 16-fold resistance, which may be mediated by ABCG2

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