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Panobinostat
Synonyms: LBH-589
CAS NO: 404950-80-7
Molecular Formula: C21H23N3O2
Molecular Weight: 349.43
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: A novel broad-spectrum HDAC(histone deacetylase) inhibitor belongs to the hydroxamate class, in Philadelphia chromosomeCnegative (Ph-) acute lymphoblastic leukemia (ALL). Histone deacetylases (HDACs) are responsible for deacetylating histones and nonhistone proteins, thus regulating gene transcription, protein function, and stability.Aberrant recruitment of HDACs has been shown to play an important role in leukemogenesis, and alterations in the expression and/or activity of HDACs have been also observed in solid tumors.The 50% inhibitory concentration (IC50) value for inhibition of proliferation in MOLT-4 cells is approximately 5 nM and for Reh cells is approximately 20 nM.Similar results were observed at 24 and 72 hours.

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