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Triciribine
Synonyms:
CAS NO: 35943-35-2
Molecular Formula: C13H16N6O4
Molecular Weight: 320.3
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt. This agent is shown≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.

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