Home Products SNS-032 (BMS-387032)
SNS-032 (BMS-387032)
Synonyms:
CAS NO: 345627-80-7
Molecular Formula: C17H24N4O2S2
Molecular Weight: 380.53
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM, respectively. SNS-032 effectively kills chronic lymphocytic leukemia cells in vitro regardless of prognostic indicators and treatment history. Compared with flavopiridol and roscovitine, SNS-032 is more potent, both in inhibition of RNA synthesis and at induction of apoptosis. SNS-032 activity is readily reversible; removal of SNS-032 reactivates RNA polymerase II, which led to resynthesis of Mcl-1 and cell survival.

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