Home Products Dasatinib (BMS-354825)
Dasatinib (BMS-354825)
Synonyms: Dasatinib (BMS-354825)
CAS NO: 302962-49-8
Molecular Formula: C22H26ClN7O2S
Molecular Weight: 488.01
Purity: 99%
Solubility: In DMSO
Storage: -20°C
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Remarks: Dasatinib (BMS-354825) is an ATP-competitive, dual SRC/ABL inhibitor. Dasatinib is a potent inhibitor of imatinib-resistant KIT activation loop mutants and induces apoptosis in mast cell and leukemic cell lines expressing these mutations. Dasatinib sensitively inhibits all members of the Src family, including c-Src, Lck, Fyn, and Yes (IC50 < 1.1nmol/L). At higher concentrations (3 to 28 nmol/L), dasatinib also inhibits the Src kinases Abl, c-Kit, PDGFR, and EphA2.

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