Home Products Cediranib (AZD2171)
Cediranib (AZD2171)
Synonyms: Cediranib (AZD2171)
CAS NO: 288383-20-0
Molecular Formula: C24H25CLFN5O3
Molecular Weight: 485.94
Purity: 98% min
Solubility: In DMSO
Storage: −20°C 2 years
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Remarks: Cediranib suppresses PDGF-AA with an IC50 of 0.04 M in MG63 cell lines. Cediranib has been shown to block Flt-1-associated kinase with an IC50 of 5 nM and VEGF-C and VEGF-D receptor Flt-4 with an IC50 of less than 3 nM. In addition, the IC50 values for inhibition of c-Kit and PDGFR- tyrosine kinase are 2 and 5 nM respectively. Furthermore, no inhibition of enzyme activity is observed when 10 M Cediranib is assayed with 100 M ATP against AMPK, Chk1 Akt/PKB and others. Micromolar concentrations of Cediranib are needed to prevent tumor cell proliferation in vitro.

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