Home Products Entinostat (MS-275, SNDX-275)
Entinostat (MS-275, SNDX-275)
Synonyms: Entinostat (MS-275, SNDX-275)
CAS NO: 209783-80-2
Molecular Formula: C21H20N4O3
Molecular Weight: 376.41
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: Entinostat (MS-275, SNDX-275) is a potent HDAC inhibitor with IC50 of 0.3 and 8µM for HDAC1 and HDAC3, respectively. Entinostat (MS-275, SNDX-275) is synthetic benzamide derivative with potential antineoplastic activity. Entinostat (MS-275, SNDX-275) has no inhibitory activity towards HDAC8 (IC50>100 µM). Entinostat (MS-275, SNDX-275) appears to exert dose-dependent effects in human leukemia cells at low concentrations in human prostate cancer cell lines. Entinostat (MS-275, SNDX-275) exerted growth arrest in PC-3 and LNCaP cells, and induced cell death in DU-145 cells.

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