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Roscovitine
Synonyms: CYC202,Seliciclib
CAS NO: 186692-46-6
Molecular Formula: C19H26N6O
Molecular Weight: 354.45
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: Biological Activity of Roscovitine (Seliciclib): Roscovitine (Seliciclib) is a potent and selective inhibitor of cyclin-dependent kinases (cdks). This agent displays higher inhibitory potency and higher selectivity compared to olomoucine.Roscovitine inhibits p34 cdc2/cyclin B (IC50 = 0.65 µM), p33 cdk2/cyclin A(IC50 = 0.70 µM), p33 cdk2/cyclin E (IC50 = 0.70 µM), and p33 cdk2/p35(IC50 = 0.20 µM) by competing for the ATP binding domain of these kinases. Roscovitine exhibits very low sensitivity towards related kinases, such as erk1 and erk2 (IC50 = 34 µM and 14 µM, respectively)

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