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Everolimus
Synonyms:
CAS NO: 159351-69-6
Molecular Formula: C53H83NO14
Molecular Weight: 958.22
Purity: 98%
Solubility: In DMSO
Storage: −20°C 2 years
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Remarks: Everolimus(RAD001), is a 40-O-(2-hydroxyethyl) derivative of rapamycin with immunosuppressant and anti-angiogenic properties, which exhibits improved aqueous solubility relative to the parent compound for oral administration. In cells, Everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of mTOR. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production

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