Home Products CB5083;CB-5083
CB5083;CB-5083
Synonyms:
CAS NO: 1542705-92-9
Molecular Formula: C24H23N5O2
Molecular Weight: 413.4
Purity: 98% min
Solubility: DMSO
Storage: -20¡æ
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Remarks: CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer.

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Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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Telmesteine
TH-302
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URB 754
UK 383367
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URB597
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VRT752271
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VR23
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WS6;WS-6;WS-6
WS3;WS-3;WS 3
WZ 811
XL019
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XL-765, SAR245409
XL388
XEN445
XMD17-109
Y27632
YM90Khydrochloride
YS-49
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Y 27632 dihydrochloride
YK 4-279
Y320;Y-320
Z-JIB-04 (NSC 693627)
ZM 241385
ZLN005
Zotarolimus A179578 ABT 578
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Zibotentan
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Z-VAD-FMK
ZSTK 474
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