Home Products PF06447475 PF 06447475
PF06447475 PF 06447475
Synonyms: PF-06447475
CAS NO: 1527473-33-1
Molecular Formula: C17H15N5O
Molecular Weight: 305.33
Purity: 98% min
Solubility: DMSO
Storage: -20°C
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Remarks: PF-06447475 inhibits LRRK2 enzyme and LRRK2 in the whole cell assay with IC50s of 3 and 25 nM, respectively. Cells incubated with PF-06447475 alone (0.5, 1, 3 ¦ÌM) or in the presence of ROT significantly reduces (S935)-LRRK2 kinase phosphorylation to control. PF-06447475 significantly preserves the nucleus morphology and ¦¤¦·m of NLCs exposed to ROT compared to untreated and control. PF-475 significantly diminishes ROT-induced ROS generation to a similar extent to cells exposed to PF-475 alone.

Quality Control

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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WAY-100635 maleate salt
WIN 55212-2 mesylate
XL-765, SAR245409
XL388
XMD17-109
XL019
XMD 8-92
XEN445
Y 27632 dihydrochloride
YM 155
YS-49
YK 4-279
Y320;Y-320
YM90Khydrochloride
Y27632
Zibotentan
ZSTK 474
Z-VAD-FMK
ZLN005
ZM323881
ZM 241385
Z-JIB-04 (NSC 693627)
Zotarolimus A179578 ABT 578
Zonisamide sodium salt
[1,1’-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E,3S)-3-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-5- phenyl-1-pentenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester
[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
 

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