Home Products CCT-244747; CCT 244747
CCT-244747; CCT 244747
Synonyms:
CAS NO: 1404095-34-6
Molecular Formula: C20H24N8O2
Molecular Weight: 408.46
Purity: 98% min
Solubility: In DMSO
Storage: -20 oC
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Remarks: CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies.

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Zotarolimus A179578 ABT 578
ZSTK 474
ZLN005
Z-VAD-FMK
ZM 241385
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ZM323881
[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
 

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