Home Products LY2784544
LY2784544
Synonyms:
CAS NO: 1229236-86-5
Molecular Formula: C23H25ClFN7O
Molecular Weight: 469.94
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: LY2784544 also inhibits IL-3-activated wild type JAK2 with IC50 of 2.26 M. Similarly in the proliferation assay, LY2784544 shows antiproliferation activity in JAK2 V617F-driven cells with IC50 of 68 nM, compared to 1.36 M in wild type JAK2-driven cells and 0.94 M in JAK3-driven cells.LY2784544 significantly inhibits STAT5 phosphorylation in Ba/F3-JAK2 V617F-GFP xenografts with a Threshold Effective Dose 50 (TED50) of 12.7 mg/kg. LY2784544 also reduces Ba/F3-JAK2 V617F-GFP tumor burden in the JAK2 V617F-induced MPN model with a TED50 of 13.7 mg/kg after oral treatment. LY2784544 has no effect on CD71/Ter119 positive erythroid progenitors in spleens of SCID mice after oral treatment.

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