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CAY10505
Synonyms:
CAS NO: 1218777-13-9
Molecular Formula: C14H8FNO3S
Molecular Weight: 289.28
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: CAY10505 is a potent PI3K inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase (PI3K) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505 also prevents other , , and isoforms with IC50 of 0.94, 20, and 20 M, respectively. CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505 also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505 decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K-deficient mice.

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