Home Products INCB024360
INCB024360
Synonyms:
CAS NO: 1204669-58-8
Molecular Formula: C11H13BrFN7O4S
Molecular Weight: 438.23
Purity: 98% min
Solubility: DMSO
Storage: -20¡æ
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Remarks: INCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC50 value <100 nM. IC50 Value: <100 nM [1] Target: Indoleamine-2,3-dioxygenase IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.

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