Home Products Brigatinib (AP-26113)
Brigatinib (AP-26113)
Synonyms:
CAS NO: 1197953-54-0
Molecular Formula: C29H39ClN7O2P
Molecular Weight: 584.09
Purity: 98% min
Solubility: DMSO
Storage: -20¡æ
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Remarks: Brigatinib is a highly potent and selective investigational ALK inhibitor with mean IC50 value £¼ 100 nM in Ba/F3 cells. IC50 value: £¼ 100 nM Target: pan-ALK in vitro: Brigatinib inhibits all 17 ALK mutants previously observed to confer resistance to Crizotinib, Ceritinib, and/or Alectinib. in vivo: Brigatinib uniquely maintains substantial activity against the highly recalcitrant G1202R mutant. Brigatinib has exhibited promising antitumor activity in patients with Crizotinib-resistant disease in an ongoing phase 1/2 clinical trial.

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