Home Products PHT-427
PHT-427
Synonyms:
CAS NO: 1191951-57-1
Molecular Formula: C20H31N3O2S2
Molecular Weight: 409.61
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: PHT-427 is a dual Akt and PDPK1 inhibitor that affects downstream targetsamong sensitive but not resistant cells and tumor xenografts. When given orally, PHT-427 inhibited the growth of human tumor xenografts in immunodeficient mice, with up to 80% inhibition in the most sensitive tumors, and showed greater activity than analogues with C4, C6, or C8 alkyl chains. Inhibition of PDPK1 was more closely correlated to antitumor activity than Akt inhibition.

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