Home Products Dofetilide
Dofetilide
Synonyms:
CAS NO: 115256-11-6
Molecular Formula: C19H27N3O5S2
Molecular Weight: 441.56
Purity:
Solubility: DMSO
Storage: -20°C 2 years
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Remarks: Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.Dofetilide blocks HERG currents in excised macro patches of Xenopus oocytes. Dofetilide (1 M) reduces the amplitude of IKr to 61% of control currents in guinea pig cardiomyocytes, as measured by 200-ms test pulses and analysis of the deactivating tail currents of IKr. Dofetilide increases apico-basal disparity of repolarization, due to a more marked increase of ERPs in the apex than in the base in the intact canine heart.

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