Home Products MK-2206
MK-2206
Synonyms:
CAS NO: 1032350-13-2
Molecular Formula: C25H21N5O.2HCl
Molecular Weight: 480.39
Purity: 98% min
Solubility: In DMSO
Storage: −20°C
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Remarks: MK-2206, a highly selective non-ATP competitive allosteric Akti, has nM IC50 and broad preclinical antitumor activity. MK-2206 is a potent allosteric Akt inhibitor with IC50 at 8 nm, 2 mM, 65 mM for Akt1, Akt2 and Akt3 respectively. 1 hr treatment of 1 M MK-2206 abolished Akt phosphorylation in U87MG cells. MK-2206 treatment abolished IR-induced Akt phosphorylation. Moreover, treatment with MK-2206 also increased the radiosensitivity of U87MG cells.

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