Home Products Vemurafenib (PLX4032)
Vemurafenib (PLX4032)
Synonyms: RG7204 Vemurafenib RO5185426
CAS NO: 1029872-54-5
Molecular Formula: C23H18ClF2N3O3S
Molecular Weight: 489.92
Purity: 98% min
Solubility: In DMSO
Storage: -20°C
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Remarks: PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas and about eight percent of all solid tumors. [2] BRAF mutant melanoma cell strains were highly sensitive to PLX4032 with IC50 in the nM range (60C450 nM), whereas BRAF wild-type cells were resistant, with IC50 2.4 M or above.

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