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BMS777607
Synonyms:
CAS NO: 1025720-94-8
Molecular Formula: C25H19ClF2N4O4
Molecular Weight: 512.89
Purity: 99%
Solubility: In DMSO
Storage: −20°C
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Remarks: BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 M. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5 mol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 mol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.

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